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Exploring wine-processing: a distinctive classic technique in TCM.

Jinbo Li1, Chao Sun2, Ajiao Hou1

  • 1Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education No. 24 Heping Road, Xiangfang Harbin 150040 China hxk_yl@163.com jianghai_777@126.com.

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Wine-processing in Traditional Chinese Medicine (TCM) enhances herb efficacy and delivery by modulating properties. Modernization requires research into optimization, quality markers, and mechanisms for clinical translation.

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Area of Science:

  • Pharmacology
  • Traditional Chinese Medicine
  • Herbal Medicine

Background:

  • Wine-processing is a traditional Chinese medicine (TCM) preparation technique refined over millennia.
  • This method uses wine-herb interactions to improve drug delivery, moderate properties, amplify effects, and reduce toxicity.

Purpose of the Study:

  • To systematically analyze the scientific literature and historical texts on wine-processing in TCM.
  • To identify research gaps and future priorities for the modernization of this traditional technique.

Main Methods:

  • Systematic literature review across multiple scientific databases (Baidu Scholar, CNKI, Google Scholar, PubMed, ScienceDirect, Web of Science, SciFinder).
  • Analysis of historical TCM texts and the 2025 Chinese Pharmacopoeia.
  • Generation of graphical abstracts using the Generic Diagramming Platform (GDP).

Main Results:

  • Wine-processing enhances channel tropism, kidney/liver tonification, and solubility of bioactive compounds.
  • Evidence supports the modulation of medicinal properties and therapeutic effects through wine-herb interactions.
  • Challenges in modernization include process parameter optimization and quality-marker discovery.

Conclusions:

  • Wine-processing is a significant TCM technique with proven benefits for enhancing herbal medicine properties and efficacy.
  • Further research is crucial for optimizing the process, discovering quality markers, and elucidating mechanisms for clinical application.
  • Advancing multi-omics studies is recommended to scientifically validate efficacy-toxicity modulation and facilitate clinical translation.