Related Experiment Video
Updated: Jan 6, 2026
05:51
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
13.7K
Distinct Roles of PPARs in Atherosclerosis.
Guofang Wang1, Yu Yan1, Qian Sun1
1Key Laboratory of Exercise and Health Sciences (Shanghai University of Sport), School of Exercise and Health, Ministry of Education, China (G.W., Y.Y., Q.S., L.C., L.L.).
Arteriosclerosis, Thrombosis, and Vascular Biology
|November 20, 2025
Summary
Peroxisome proliferator-activated receptors (PPARs) play complex roles in atherosclerosis, influencing lipid metabolism and inflammation. Understanding these nuclear receptors offers potential for new cardiovascular disease treatments.
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Endocrinology
Background:
- Atherosclerosis is a major cause of cardiovascular disease, characterized by lipid issues, endothelial dysfunction, and inflammation.
- Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating metabolism and inflammation.
- PPARs have diverse, context-dependent effects on atherosclerosis across different tissues and cell types.
Purpose of the Study:
- To review the functions and molecular mechanisms of PPARs in atherosclerosis development and treatment.
- To focus on PPAR roles in lipid metabolism, inflammation, and vascular remodeling.
- To evaluate therapeutic strategies targeting PPARs and identify research gaps.
Main Methods:
- Literature review of studies on PPARs and atherosclerosis.
- Analysis of molecular mechanisms underlying PPAR functions.
- Evaluation of preclinical and clinical data on PPAR-targeted therapies.
Main Results:
- PPARs significantly impact lipid metabolism, reducing atherogenic lipid levels.
- PPAR activation modulates inflammatory pathways, decreasing immune cell infiltration in vessels.
- PPARs influence vascular remodeling processes, affecting plaque stability and progression.
Conclusions:
- PPARs are critical regulators in atherosclerosis, with multifaceted roles.
- Targeting PPARs presents a promising therapeutic avenue for cardiovascular diseases.
- Further research is needed to fully elucidate PPAR functions and optimize therapeutic strategies.
Related Concept Videos
01:30Peripheral Artery Disease I: Introduction
275
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
275
01:30Atherosclerosis I: Introduction
738
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
738
01:26Atherosclerosis III: Management
290
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
290
01:30Coronary Artery Disease I: Introduction
843
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
843
01:26Coronary Artery Disease II: Pathophysiology
332
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
332
01:38Inflammation
61.4K
Overview
61.4K