High frequency acoustofluidic based controllable drug delivery system.

Area of Science:

• Biomedical Engineering
• Drug Delivery Systems
• Acoustics

Background:

• Current drug delivery systems struggle to meet diverse patient needs in personalized medicine.
• Controllable release profiles are crucial for effective long-term therapies.

Purpose of the Study:

• To develop a novel drug delivery system with controllable zero-order and first-order release profiles.
• To investigate the impact of acoustofluidics on drug release modulation.

Main Methods:

• Utilized a hydrodynamic method combining nanochannels with gigahertz (GHz) acoustofluidics.
• Employed finite element method simulations to analyze acoustic streaming and molecular concentration.
• Demonstrated modulation of FITC-dextran release and *in vitro* first-order release using a wirelessly powered implantable drug delivery system (GADDS).

Main Results:

• Achieved controllable drug release (zero-order and first-order) using GHz acoustofluidics.
• Demonstrated tunable release rates (slow at low power, enhanced at high power).
• Successfully modulated *in vitro* first-order release with a GADDS.

Conclusions:

• The developed system offers a new platform for precision drug delivery.
• This technology advances personalized medicine by enabling tailored therapeutic profiles.
• Paves the way for next-generation acoustic drug delivery devices.