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Association of Systemic Inflammatory Response Index (SIRI) With Severity of Coronary Artery Disease in Patients With

Wenli Chen1, Yuanyuan He1, Cun Xie2,3

  • 1Tianjin University of Traditional Chinese Medicine, China.

Angiology
|November 20, 2025
PubMed

Insights

The systemic inflammation response index (SIRI) can help determine coronary heart disease (CHD) severity. Higher SIRI levels are linked to more severe CHD, especially in females and older adults.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Public Health

Background:

  • The systemic inflammation response index (SIRI) is a novel biomarker for chronic inflammation.
  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Assessing CHD severity is crucial for effective patient management.

Purpose of the Study:

  • To evaluate the clinical utility of SIRI in determining the severity of coronary heart disease (CHD).
  • To investigate the association between SIRI levels and the extent of coronary artery disease.

Main Methods:

  • Analysis of data from the Cohort Study on the Treatment of Cardiovascular Diseases with Traditional Chinese Medicine (CSCD-TCMplus).
  • Participants (n=7706) were categorized into tertiles based on SIRI values.
  • Logistic regression analysis was employed to assess the relationship between SIRI and CHD severity (number of diseased vessels).

Main Results:

  • A significant association was found between higher SIRI levels and increased CHD severity (OR: 1.09, 95% CI: 1.03-1.15).
  • Females and individuals over 55 years old showed a higher risk of severe CHD with elevated SIRI.
  • The association remained significant after adjusting for confounding factors.

Conclusions:

  • SIRI is a valuable biomarker for assessing CHD severity.
  • Inflammation, as indicated by SIRI, plays a significant role in the progression of coronary heart disease.
  • Further research may explore SIRI's role in guiding treatment strategies for CHD.

Keywords:
coronary heart diseaseinflammationsystemic inflammatory response index

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