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[Higher-level ambulation disorders in Parkinson's disease]
P S Dynin1, I V Litvinenko1, D N Frunza1
1S.M. Kirov Military Medical Academy, St. Petersburg, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 20, 2025
Summary
Parkinson's disease ambulation disorders involve motor and cognitive deficits, complicated by aging and comorbidities. Effective treatment requires combined drug and non-drug therapies for improved mobility.
Area of Science:
- Neurology
- Gerontology
- Movement Disorders
Background:
- Ambulation disorders in Parkinson's disease (PD) stem from disease progression and aging.
- Multisensory impairments and the motor-cognitive deficit are key factors.
- Diagnosis is challenging due to varied causes, including ineffective standard therapies, cognitive impairments, and comorbidities.
Purpose of the Study:
- To explore the complexities of diagnosing and treating ambulation disorders in Parkinson's disease.
- To investigate the link between gait changes and cognitive decline.
- To highlight modern diagnostic and therapeutic approaches.
Main Methods:
- Review of factors influencing ambulation in PD.
- Discussion of diagnostic challenges and the role of gait patterns.
- Exploration of advanced therapeutic strategies.
Main Results:
- Gait pattern changes may indicate cognitive deficit progression.
- Standard antiparkinsonian therapy can be ineffective.
- Combined drug and non-drug treatments are crucial for advanced cases.
Conclusions:
- Effective management of PD ambulation disorders necessitates a comprehensive approach.
- Integrated therapies, including transcranial magnetic stimulation and ergometric exercises, show promise.
- Anticholinesterase agents may play a role in treatment regimens.
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