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Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

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Spatial transcriptomics: challenges and future directions in musculoskeletal diseases.

Keemo Delos Santos^1,2, Jason S Rockel¹, Mohit Kapoor^1,2,3

¹Schroeder Arthritis Institute, University Health Network.

Current Opinion in Rheumatology

|November 20, 2025

Summary

Spatial transcriptomics reveals gene expression within musculoskeletal tissues, advancing research into complex diseases. This technology offers new therapeutic avenues by detailing cellular and molecular insights.

Keywords:

musculoskeletal diseases next-generation sequencing spatial transcriptomics

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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Published on: July 6, 2022

Area of Science:

Biomedical Research
Genomics
Molecular Biology

Background:

Next-generation sequencing enhances understanding of musculoskeletal (MSK) system heterogeneity.
Spatial transcriptomics enables in-situ gene expression analysis on intact tissues.

Purpose of the Study:

To review advancements in spatial transcriptomics for MSK research.
To explore current and potential applications in understanding MSK diseases.
To identify challenges and opportunities for spatial transcriptomics in MSK research.

Main Methods:

Review of emerging spatial transcriptomic techniques.
Analysis of spatial transcriptomics applications in MSK disease research.

Main Results:

Spatial transcriptomics provides in-situ gene expression data from MSK tissues.
Understanding spatial transcriptomes illuminates the complexity of MSK diseases.
Identified challenges and opportunities for broader MSK application.

Conclusions:

Spatial transcriptomics is a powerful tool for MSK research.
Addressing current challenges can improve spatial transcriptomics insights in MSK tissues.
Future considerations aim to enhance the utility of spatial transcriptomics for therapeutic development.