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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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The Complex Interplay Between Aging, Cardiac Remodeling, and Atrial Fibrillation

Tammy Ryan1, Carlos A Morillo2, José Jalife3

  • 1Libin Cardiovascular Institute, University of Calgary Health Research Innovation Centre, Calgary, Alberta, Canada.

JACC. Clinical Electrophysiology
|November 20, 2025
PubMed

Insights

Aging significantly increases atrial fibrillation risk. Research explores underlying mechanisms like fibrosis and inflammation to understand this public health challenge.

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Pathophysiology

Background:

  • Aging is a primary risk factor for atrial fibrillation.
  • The aging global population exacerbates this public health concern.
  • Specific mechanisms linking aging to atrial fibrillation are not fully understood.

Purpose of the Study:

  • To review recent research on the link between aging and atrial fibrillation.
  • To focus on the basic pathophysiological mechanisms involved.
  • To identify areas for future research.

Main Methods:

  • Literature review of studies from the last several years.
  • Focus on basic science and pathophysiological mechanisms.
  • Synthesis of current understanding and identification of knowledge gaps.

Main Results:

  • Several biological processes implicated: fibrosis, DNA damage, chromatin remodeling, amyloid deposition, mitochondrial dysfunction, and inflammation.
  • These processes contribute to structural and functional atrial changes.
  • Current research highlights multiple contributing factors to age-related atrial remodeling.

Conclusions:

  • Aging-associated pathophysiological changes are central to atrial fibrillation development.
  • Further research is needed to fully elucidate the complex relationship between aging and atrial fibrillation.
  • Understanding these mechanisms may lead to targeted interventions for age-related cardiovascular diseases.

Keywords:
agearrhythmiasconduction abnormalitieselectrical remodelingpacemakerstructural remodeling

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