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Association Between Cancer Treatment History and Coronary Inflammation
Nariko Tsukamoto1, Ayako Kunimura1, Shimpei Kuno1
1Department of Cardiology, Aichi Medical University, Nagakute, Aichi, Japan.
JACC. Advances
|November 20, 2025
Summary
A cancer history is linked to increased coronary inflammation, a key factor in atherosclerosis. This risk is particularly high for patients recently treated for cancer, highlighting a need for cardiovascular monitoring.
Area of Science:
- Cardiology
- Oncology
- Medical Imaging
Background:
- Established link between cancer history and increased cardiovascular events.
- Coronary inflammation is a critical factor in atherosclerotic plaque development.
Purpose of the Study:
- To investigate the independent association between a cancer history and coronary inflammation.
- To assess coronary inflammation using the perivascular fat attenuation index (FAI).
Main Methods:
- Included 1141 patients undergoing coronary computed tomography angiography.
- Quantified coronary inflammation via the perivascular fat attenuation index (FAI).
- Used multivariable Poisson regression to analyze the relationship between cancer history and high-FAI, adjusting for cardiovascular risk factors.
Main Results:
- Cancer patients showed a significantly increased prevalence of high-FAI (RR: 1.56).
- Patients within 5 years post-cancer treatment had a higher association with high-FAI (RR: 1.70).
- No significant association was found for patients ≥5 years post-treatment.
Conclusions:
- A cancer history is significantly associated with elevated coronary inflammation.
- Recent cancer treatment history is a key factor in this association.
- Findings suggest increased cardiovascular risk in cancer survivors, particularly those recently treated.
Keywords:
cardiovascular diseasecoronary computed tomography angiographyfat attenuation indexmalignancyperi-coronary adipose tissueMore Related Videos
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