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Metastatic Pleomorphic Adenoma: A Systematic Review.
Alberto Jose Peraza-Labrador1, Doreen Palsgrove2, Marcelo Villacis3
1Department of Diagnostic Sciences, Texas A&M University College of Dentistry. Dallas, 3302 Gaston Avenue, Texas, zip code 75246, USA. aperaza@tamu.edu.
Head and Neck Pathology
|November 20, 2025
Summary
Metastatic pleomorphic adenoma (MPA) is a rare condition where benign-appearing tumors spread to distant sites. Diagnosis requires careful clinical, histopathological, and imaging correlation with long-term follow-up.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Metastatic pleomorphic adenoma (MPA) presents as a histologically benign pleomorphic adenoma with metastasis to regional and distant sites.
- This paradoxical behavior occurs despite the absence of malignant histological features.
Conclusions:
- MPA is a rare entity with benign histology but malignant behavior (metastasis), often after recurrences.
- Diagnosis necessitates correlation of clinical, histopathological, and imaging findings.
- Long-term follow-up is crucial after pleomorphic adenoma surgery.
