Progression of cognitive and functional decline before and after stroke: evidence from four prospective cohort studies across 23 countries
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View abstract on PubMed
Summary
This summary is machine-generated.Stroke accelerates cognitive decline, beginning even before the event and continuing afterward. This highlights the critical need for cognitive assessments in stroke care and prevention strategies.
Area Of Science
- Neuroscience
- Gerontology
- Public Health
Background
- Previous studies on stroke's cognitive impact yielded inconsistent results.
- Lack of pre-stroke cognitive data hindered distinguishing stroke effects from normal aging.
Purpose Of The Study
- To investigate cognitive and functional changes before and after stroke.
- To compare cognitive trajectories in stroke patients versus stroke-free individuals internationally.
Main Methods
- Analysis of data from four international longitudinal cohort studies (CHARLS, ELSA, HRS, SHARE) across 23 countries.
- Utilized a two-level growth model to estimate cognitive trajectories post-stroke.
Main Results
- Stroke patients exhibited faster pre-stroke cognitive decline compared to stroke-free individuals.
- Stroke was associated with an immediate global cognitive drop and accelerated subsequent decline.
- Cognitive domains including memory, orientation, and executive function showed post-stroke decline.
Conclusions
- Stroke leads to acute cognitive reduction and accelerated ongoing decline, commencing pre-stroke.
- Emphasizes the necessity of multidimensional outcome measures in stroke care.
- Highlights the importance of prioritizing cognitive health in stroke prevention and management.
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