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Pulse rhythm

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
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Updated: Jan 10, 2026

A Community-based Stress Management Program: Using Wearable Devices to Assess Whole Body Physiological Responses in Non-laboratory Settings

A Community-based Stress Management Program: Using Wearable Devices to Assess Whole Body Physiological Responses in Non-laboratory Settings

Published on: January 22, 2018

Measuring Fatigue and Heart Rate Variability Using A Wearable Patch in Ulcerative Colitis Patients: A Cross-Sectional

Paula I Metselaar¹, Mees J van der Hoff², Tim J van den Broek³

¹Tytgat Institute for Liver and Intestinal Research, AGEM, Amsterdam UMC.

Journal of Clinical Gastroenterology

|November 20, 2025

Summary

A wearable vital signs patch could not distinguish ulcerative colitis (UC) disease activity or fatigue severity using heart rate variability (HRV). However, HRV showed associations with inflammation markers, suggesting further research is needed.

Keywords:

fatigue heart rate variability quality of life ulcerative colitis wearables

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Area of Science:

Cardiology
Gastroenterology
Biomedical Engineering

Background:

Ulcerative colitis (UC) significantly impacts quality of life, with fatigue being a common yet overlooked symptom.
Heart rate variability (HRV) shows potential for detecting inflammation onset in UC patients.

Purpose of the Study:

To explore the capability of a novel wearable vital signs patch in assessing UC disease activity and fatigue severity via HRV.
To investigate associations between HRV metrics and various patient-reported outcomes and biochemical markers.

Main Methods:

A cross-sectional pilot study involved 72-hour remote HRV monitoring using a noninvasive wearable device in UC patients.
Associations were analyzed between multiple HRV metrics and fatigue, anxiety, depression, quality of life, clinical symptoms, and biochemical disease activity markers.

Main Results:

No significant differences in HRV metrics were found between clinically active and quiescent UC, or between fatigued and non-fatigued patients.
Two HRV metrics correlated with biochemical disease activity; age, sex, and antidepressant use influenced HRV.
A strong correlation was observed between fatigue and depression in UC patients.

Conclusions:

The wearable vital signs patch did not differentiate UC disease activity or fatigue severity based on HRV.
Associations between HRV and biochemical inflammation markers suggest potential, warranting further investigation in larger cohorts.