Related Experiment Video

Updated: Jan 10, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

695

Association of Glycemic Variability with Mortality among Septic Patients with Coronary Artery Disease: A Multicenter

Hongda Hou1,2, Zheng Guo3, Xueyan Wang1,2

  • 1Institute of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin, China.

Journal of Intensive Care Medicine
|November 20, 2025
PubMed

Insights

Higher glycemic variability (GV) significantly increases in-hospital mortality for septic patients with coronary artery disease (CAD). Managing GV may improve outcomes in this high-risk group.

Area of Science:

  • Critical care medicine
  • Cardiology
  • Endocrinology

Background:

  • Septic patients with coronary artery disease (CAD) have high mortality risks.
  • Glycemic variability (GV) may worsen outcomes in these patients.

Purpose of the Study:

  • To investigate the association between GV and mortality in septic patients with CAD.
  • To analyze in-hospital and 1-year mortality in relation to GV.

Main Methods:

  • Retrospective analysis of MIMIC-IV and THMDP databases.
  • Inclusion of sepsis patients with CAD and at least three blood glucose measurements.
  • Definition of GV using the coefficient of variation; categorization into quartiles.
  • Application of Cox proportional hazards models and restricted cubic spline analyses.

Main Results:

  • Higher GV was significantly associated with increased in-hospital mortality in both cohorts.
  • Pooled analysis confirmed a significant link between higher GV and in-hospital mortality (adjusted HR 1.65).
  • No significant association was found between GV and 1-year mortality.

Conclusions:

  • Elevated glycemic variability is an independent predictor of in-hospital mortality in septic patients with CAD.
  • GV management may be crucial for improving short-term outcomes in this population.
  • Further research is needed to explore GV stabilization strategies.

Keywords:
MIMIC-IVTHMDPcoronary artery diseaseglycemic variabilitymortalitysepsis

More Related Videos

Improving IV Insulin Administration in a Community Hospital12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
330
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
311
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
577
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
857