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Published on: November 1, 2024
Helicobacter pylori Infection Is Associated with Leukoaraiosis without Lesion Location Correlation
Pingping Jin1, Qiong Yao1, Yanyan Zheng1
1Neurology Department, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, China.
Introduction:
Leukoaraiosis, common focal lesion, is associated with cognitive impairment, gait abnormalities, and depression. Helicobacter pylori is an intragastric pathogen that has been implicated in extraintestinal disease. This study explored the relationship between leukoaraiosis and H. pylori infection, and analyzed the H. pylori infection in different white matter lesion sites.
Methods:
A total of 350 patients underwent cranial MRI and H. pylori testing. Patients were divided into leukoaraiosis group (n = 149) and non-leukoaraiosis group (n = 201), with basic information collected and leukoaraiosis locations recorded based on FLAIR images in MRI. Basic characteristics were compared between the two groups, and a multivariate logistic regression model was used to identify independent risk factors for leukoaraiosis.
Results:
Patients with leukoaraiosis were older (p = 0.009) and had a higher proportion of smoking (p = 0.032) and hypertension (p < 0.0001) compared to those without leukoaraiosis. H. pylori infection was more prevalent in the leukoaraiosis group (p < 0.0001). However, the distribution of H. pylori infection across different lesion sites did not differ significantly (p = 0.839).
Conclusion:
H. pylori infection is associated with leukoaraiosis, possibly through mechanisms such as chronic inflammatory responses, blood-brain barrier damage, and vascular endothelium damage. Nevertheless, no variation in H. pylori infection was observed among different cerebral white matter lesion locations. Future prospective studies are warranted to validate these findings.
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