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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
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Integrated knowledge translation (iKT) in preclinical research: A scoping review protocol
Georgia Black1, Reena Besa2, Daniel Blumberger2,3,4
1Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Plos One
|November 20, 2025
Summary
Integrated knowledge translation (iKT) is a collaborative research method. This scoping review will explore its use, benefits, and challenges in preclinical research to improve study relevance and application.
Area of Science:
- Health Research
- Preclinical Research
- Knowledge Translation
Background:
- Integrated knowledge translation (iKT) involves active knowledge user participation in research.
- iKT can enhance research relevance, applicability, and uptake.
- The application and effectiveness of iKT in preclinical research are not well understood.
Purpose of the Study:
- To conduct a scoping review mapping the current use of iKT in preclinical research.
- To identify potential benefits and challenges associated with implementing iKT in preclinical settings.
- To address the knowledge gap regarding iKT's role in preclinical research.
Main Methods:
- Systematic search of multiple databases (Medline, Embase, PsycINFO, etc.) and reference lists.
- Inclusion of peer-reviewed English articles on iKT or aligned approaches in preclinical research.
- Utilizing a modified Arksey and O'Malley scoping review framework.
Main Results:
- This section is to be filled after the review is completed.
Conclusions:
- This section is to be filled after the review is completed.
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