Related Experiment Video

Updated: Jan 10, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

517

Outcome of infants with bronchopulmonary dysplasia

Dwi Kisworo Setyowireni1, Roni Naning1, Rina Triasih1

  • 1Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Plos One
|November 20, 2025
PubMed

Insights

Infants with bronchopulmonary dysplasia (BPD) face a high mortality risk, with nearly half dying within seven months. Prematurity (post-menstrual age < 28 weeks) significantly increases this risk, while mechanical ventilation may offer protection.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Public Health

Background:

  • Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants.
  • Yogyakarta, Indonesia, presents a specific demographic for studying BPD outcomes.

Purpose of the Study:

  • To evaluate the outcomes of infants diagnosed with BPD in Yogyakarta.
  • To identify predictors of mortality in infants with BPD.

Main Methods:

  • Retrospective cohort study of infants with BPD (Jan 2015-Dec 2020).
  • Medical records review and clinical assessment including echocardiogram for survivors.
  • Multivariate logistic regression analysis to determine mortality predictors.

Main Results:

  • 1.2% of 8,490 newborns developed BPD; 48.2% of 85 infants with complete data died within 7 months.
  • Neonatal sepsis and congenital heart disease were common comorbidities.
  • Post-menstrual age < 28 weeks (OR 5.27) and mechanical ventilation (OR 0.26) were independent predictors of mortality.

Conclusions:

  • Nearly half of infants with BPD died within seven months.
  • Post-menstrual age less than 28 weeks is a significant risk factor for mortality.
  • Mechanical ventilation demonstrated a protective effect against mortality in this cohort.
Abstract

More Related Videos

Intratracheal Instillation of Stem Cells in Term Neonatal Rats04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

6.0K
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

51.9K

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
3.0K
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
64.1K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
706
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
992
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
6.0K