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Updated: Jan 10, 2026

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
Published on: November 2, 2021
GlycoRNA research: from unknown unknowns to known unknowns
Li Yi1,2, Yitong Zhou1,2, Chi Zhang1,2
1NHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Abstract:
Recent discoveries have revealed the existence of glycosylated RNAs (glycoRNA), in which glycans are covalently linked to small non‑coding RNAs and are predominantly localized to the cell surface. Since the initial discovery in 2021, glycoRNA has become an emerging field: 4 years in glycoRNA research have produced advances in labeling, imaging, and mass spectrometry that now highlight the role of glycoRNA in cell communication, immune regulation, and disease progression. In this review, we summarize current knowledge of glycoRNA biogenesis, detection techniques, and biological functions, and discuss how these findings reshape the future interface between glycobiology and RNA biology.
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