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Updated: Jan 10, 2026
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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
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Percutaneous Closure of Atrial Septal Defects With Bidirectional or Right-to-Left Shunts
Alessia Callegari1, Mathilde Meot1, Diala Khraiche1
1Centre de Référence Malformations Cardiaques Congénitales Complexes-M3C, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Summary
Percutaneous closure of atrial septal defects (ASD) is effective for patients with complex shunts. This study shows favorable outcomes and normal right ventricular function post-procedure, highlighting the importance of careful patient selection.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Atrial septal defect (ASD) closure in patients with bidirectional or right-to-left shunts poses significant challenges.
- Indications, procedural techniques, and follow-up require careful consideration in this high-risk population.
Purpose of the Study:
- To evaluate the outcomes of percutaneous ASD closure in patients with bidirectional or right-to-left shunts.
- To identify factors influencing success and complications in this challenging cohort.
Main Methods:
- Retrospective study of 47 patients undergoing percutaneous ASD closure.
- Analysis of clinical features, procedural details, and short- and long-term outcomes.
- Echocardiography and hemodynamic assessments were utilized.
Main Results:
- 89.4% of patients had desaturation as the primary indication for closure.
- Successful first-attempt closure was achieved in 81.1% of cases, primarily using the Amplatzer Septal Occluder.
- Despite early deaths in 6.4% of patients, 83.7% showed normal right ventricular function at a median 4.7-year follow-up.
Conclusions:
- Percutaneous ASD closure is a viable option with favorable outcomes, even in high-risk patients with complex shunts.
- Careful patient selection and tailored procedural strategies are crucial for optimizing results and minimizing complications.
