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Updated: Jan 10, 2026

Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method
Published on: December 25, 2016
A novel click-derived macrocyclic triazolium for fluorescent turn-on sensing of nitrite ions
Geng-Jin-Sheng Cheng1, Jing Li2, Yuyang Zhao2
1College of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, PR China; School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, PR China.
Abstract:
Organic macrocyclic receptors are a hot topic in the supramolecular recognition field. In this study, a novel click-derived macrocyclic triazolium TPETN were designed and synthesized, which incorporates tetraphenylethylene as a fluorophore and features triazolium and amide hydrogen as anions binding sites. This receptor was specifically intended for fluorescent turn-on sensing of nitrite ions (NO2-). TPETN exhibits typical aggregation-induced emission (AIE) properties and selectively binds to nitrite ion with a 1:1 stoichiometric ratio, resulting in a substantial fluorescence enhancement. Consequently, TPETN shows a low detection limit of 3.01 nM for NO2- in aqueous solution, and is effective for the detection NO2- in food and living cells.
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