Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

180
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
180
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

214
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
214
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

212
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
212
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

217
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
217
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

186
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
186

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral neuropathy as a presenting feature of familial early onset Alzheimer's disease: a rare clinical association.

Acta neurologica Belgica·2026
Same author

Whole-genome sequencing of 197 cases with Parkinson's disease reveals novel pathogenic variants in the Indian population.

NPJ Parkinson's disease·2026
Same author

Cerebral venous thrombosis-related stroke in India: Clinical patterns, risk factors, and outcomes from the hospital-based stroke registry programme.

The Indian journal of medical research·2026
Same author

Prevalence and state-dependent patterns of non-motor fluctuations in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Hypogonadotrophic hypogonadism in GBA2 associated spastic paraplegia type 46 (SPG46): a phenotypic expansion.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Development of a Composite Clinicopathological Scoring System for Enhancing Diagnostic Accuracy of Vasculitic Neuropathy: A Pilot Study.

Annals of Indian Academy of Neurology·2026

Related Experiment Video

Updated: Jan 10, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K

Is migraine in the elderly a distinct entity? A comparative cross-sectional study.

Neerupaka Venkatachalam1, Pooja Mailankody1, Seshagiri Dv1

  • 1Department of Neurology, National Institute of Mental Health & Neuro Sciences, Hosur Road, Bangalore 560029 Karnataka, India.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|November 20, 2025
PubMed
Summary

Migraine in the elderly is more frequent but less severe and disabling than in younger adults. However, older individuals experience higher rates of medication overuse headache, depression, and poor sleep quality.

Keywords:
AnxietyComorbidityDepressionDisabilityElderlyMigraine

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.6K

Related Experiment Videos

Last Updated: Jan 10, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.7K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.6K

Area of Science:

  • Neurology
  • Geriatrics
  • Clinical Research

Background:

  • Migraine characteristics, disability, and comorbidities in the elderly are not well-defined.
  • A comparative analysis between elderly and young migraine patients is needed.

Purpose of the Study:

  • To investigate headache characteristics, treatment, disability, and comorbidities in elderly migraine patients.
  • To compare these factors with those in younger migraine patients.

Main Methods:

  • A comparative cross-sectional study of 154 migraine patients (81 elderly, 73 young).
  • Assessment of headache features, disability (Migraine Disability Assessment Questionnaire), severity (Visual Analogue Scale), anxiety, depression, and sleep quality.

Main Results:

  • Elderly migraine patients had less throbbing, more holocranial, more frequent, less severe, and less disabling headaches.
  • Higher prevalence of medication overuse headache, depression, and poor sleep quality was observed in the elderly group.

Conclusions:

  • Migraine in the elderly presents as less severe and disabling despite being more frequent.
  • Increased prevalence of medication overuse headache, depression, and poor sleep quality in elderly migraineurs suggests a distinct disease entity.