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Chalcone analog-based 5-reductase 1 inhibition in neurosteroidogenesis: Mechanistic insights from integrated SPR

Chentao Ding1, Yinghao Huang1, Huidan Lian2

  • 1Department of Anesthesiology and Perioperative Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University; Key Laboratory of Pediatric Anesthesiology, Ministry of Education; Key Laboratory of Precision Anesthesiology of Zhejiang Province, Wenzhou Medical University; Wenzhou, Zhejiang 325027, China; Key Laboratory of Environment and Male Reproductive Medicine of Wenzhou, and Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, 325000, Zhejiang Province, China.

Bioorganic Chemistry
|November 20, 2025
PubMed

Keywords:
5α-reductase type 1Chalcone analogsDihydrotestosterone inhibitionNeurosteroid modulationPharmacophore modelingStructure-activity relationship

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