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Updated: Aug 9, 2026

Giant Liposome Preparation for Imaging and Patch-Clamp Electrophysiology
Published on: June 21, 2013
Electrospun proliposomes and the quest to overcome liposome instability
Ruchika1, Sudesh Kumar Yadav2, Ankit Saneja1
1Formulation Laboratory, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061 HP, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Abstract:
Electrospun proliposomes are an innovative solid-state drug delivery approach in which amphiphilic nanofibers, composed of a hydrophilic polymer, phospholipids, and therapeutic agent(s), are fabricated via electrospinning. These nanofibers stabilize lipids in a dry matrix and spontaneously self-assemble into nanoscale liposomes upon hydration. The integration of liposomes with electrospun nanofibrous scaffolds represents an innovative approach, creating a synergistic nanoscale drug delivery system that combines the complementary advantages of both liposomal and nanofiber technologies. The templating effect of nanofibers, combined with polymer carriers, enhances stability, facilitates the dispersion of therapeutic agent(s), and enables on-demand liposome formation. This opinion article highlights the principles of the in situ proliposome method and the advantages, therapeutic applications, challenges, and opportunities of electrospun proliposomes, positioning them in the broader quest to overcome liposome instability.
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