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Distinct multidimensional anger profiles predict current and long-term chronic pain outcomes.

Marine Granjon1, Noel Vest2, Sean C Mackey3

  • 1Institute of Biomedical and Oral Research, Hebrew University of Jerusalem, Israel; Department of Psychology, University of Innsbruck, Austria.

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|November 20, 2025
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Summary
This summary is machine-generated.

Chronic pain patients exhibit distinct anger profiles, with higher anger and perceived injustice linked to worse pain outcomes. Identifying these profiles can improve risk stratification and personalized pain care.

Keywords:
AngerChronic painHigh impact chronic painLatent profile analysisPerceived injustice

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Area of Science:

  • Psychology
  • Pain Medicine
  • Health Services Research

Background:

  • Anger is common in chronic pain (CP), often worsening distress and disability.
  • Understanding the interplay of anger dimensions is crucial for effective CP management.
  • Current research often overlooks the multifaceted nature of anger in chronic pain.

Purpose of the Study:

  • To identify distinct anger profiles in individuals with CP using latent profile analysis (LPA).
  • To examine the association of these anger profiles with pain outcomes cross-sectionally and longitudinally.
  • To determine if anger profiles predict pain outcomes beyond anxiety and depression.

Main Methods:

  • Utilized latent profile analysis (LPA) on anger metrics from 735 adult CP patients.
  • Assessed state/trait anger, anger expression/control, and perceived injustice.
  • Examined associations with pain intensity, distribution, interference, behavior, and physical function at baseline and follow-up (n=242).

Main Results:

  • Identified four distinct anger profiles based on anger levels and perceived injustice.
  • These profiles significantly correlated with pain outcomes at baseline and follow-up, independent of anxiety and depression.
  • Profiles with medium-to-high anger and perceived injustice predicted the most severe pain outcomes.

Conclusions:

  • Multidimensional anger profiles, especially those involving perceived injustice, are associated with high-impact chronic pain.
  • Early identification of these profiles can aid in risk stratification and personalized pain management.
  • Tailored, anger-focused interventions are essential for improving long-term outcomes in chronic pain patients.