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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jan 10, 2026

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

Published on: December 17, 2014

Age-Related Variations in Cerebrovascular Reactivity Measured With Resting-State BOLD MRI.

Mei-Yu Yeh^1,2, Changwei W Wu^3,4, Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.

NMR in Biomedicine

|November 20, 2025

Summary

This summary is machine-generated.

Resting-state relative cerebrovascular reactivity (RS-rCVR) mapping reveals localized age-related declines in brain vascular health. Voxel-wise analysis highlights these changes, while region-of-interest approaches may obscure them.

Keywords:

age effect blood oxygenation level dependent (BOLD)cerebrovascular reactivity (CVR)functional magnetic resonance imaging (fMRI)resting state (RS)

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Area of Science:

Neuroimaging
Vascular Biology
Gerontology

Background:

Cerebrovascular reactivity (CVR) is vital for brain health and declines with age.
Resting-state BOLD MRI-based relative CVR (RS-rCVR) mapping offers a noninvasive method for assessing CVR, suitable for lifespan studies.
Aging is associated with cerebrovascular decline, impacting brain function and health.

Purpose of the Study:

To investigate age-related differences in RS-rCVR in healthy adults.
To compare the sensitivity of voxel-wise versus region-of-interest (ROI) analyses in detecting age-related RS-rCVR changes.
To explore the spatial heterogeneity of cerebrovascular aging using RS-rCVR.

Main Methods:

Recruited 54 healthy adults (27 younger, 27 older).
Acquired resting-state fMRI data at 3T using a T2*-weighted gradient-echo EPI sequence.
Generated RS-rCVR maps via linear regression and performed voxel-wise and ROI-based group comparisons.

Main Results:

The distribution of RS-rCVR values differed significantly between younger and older adults (p < 0.001).
Voxel-wise analysis revealed age-related RS-rCVR reductions in the medial frontal cortex, precuneus, and cuneus.
ROI-averaged analyses showed no significant group differences, indicating that averaging can obscure localized effects.

Conclusions:

Voxel-wise RS-rCVR mapping effectively detects spatially localized age-related reductions in cerebrovascular reactivity.
ROI-based analysis may mask subtle, regionally specific age-related changes in CVR due to anatomical averaging.
These findings highlight the spatial heterogeneity of cerebrovascular aging and support voxel-level RS-rCVR for lifespan research.