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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Jan 10, 2026

Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

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Published on: March 30, 2021

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Focal Therapies for Localized Prostate Cancer.

Jibriel Noun1, Ruben Blachman-Braun1, Eugene Lee1

  • 1Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

The Urologic Clinics of North America
|November 20, 2025
PubMed
Summary

Focal therapy offers a promising treatment for localized prostate cancer (PCa), balancing active surveillance and radical options. Further long-term data is needed to fully assess its outcomes and benefits.

Keywords:
CryoablationFocal therapyHigh-intensity focused ultrasoundIrreversible electroporationLaser ablationMagnetic resonance imagingProstate cancerTransurethral ultrasound ablation

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Area of Science:

  • Oncology
  • Urology
  • Medical Technology

Background:

  • Technological advancements in prostate cancer (PCa) diagnostics have improved detection.
  • Focal therapy presents a novel treatment strategy for localized PCa.
  • It serves as an intermediate option between active surveillance and whole-gland treatments.

Purpose of the Study:

  • To evaluate focal therapy as a treatment for localized prostate cancer.
  • To explore its potential in preventing local progression and metastasis.
  • To reduce the morbidity associated with traditional whole-gland therapies.

Main Methods:

  • Treatment selection is based on index lesion characteristics, patient factors, and surgeon expertise.
  • Various energy sources and approaches are utilized in focal therapy.
  • Patient selection is crucial for successful outcomes.

Main Results:

  • Focal therapy aims to preserve prostate function while treating cancer.
  • It offers a less morbid alternative to radical treatments for select patients.
  • The precise outcomes and long-term efficacy require further investigation.

Conclusions:

  • Focal therapy is a promising approach for localized prostate cancer in select patients.
  • Careful patient selection and technique are essential for optimal results.
  • Long-term prospective studies are necessary to validate the efficacy and safety of focal therapy.