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Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Prostate Cancer Grading: An Update.

John Hanna¹, Gennady Bratslavsky², Liang Cheng³

¹Department of Pathology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.

The Urologic Clinics of North America

|November 20, 2025

Summary

This summary is machine-generated.

Recent prostate cancer grading updates improve accuracy but present challenges. Pathologists face difficulties with subjective pattern identification and sectioning, causing variability in grading prostate cancer.

Keywords:

Atypical intraductal proliferation Gleason grade groups Intraductal carcinoma Prostate cancer grading

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Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

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Published on: July 11, 2025

Area of Science:

Urology
Pathology
Oncology

Background:

Updated prostate cancer grading guidelines aim for improved prognostic accuracy.
New guidelines include grade groups, pattern 4 percentage, intraductal carcinoma, and cribriform patterns.

Purpose of the Study:

To highlight the challenges faced by pathologists in implementing new prostate cancer grading guidelines.
To identify areas of subjectivity and technical difficulty in daily practice.

Main Methods:

Review of recent changes in prostate cancer grading guidelines.
Analysis of common difficulties encountered by pathologists in daily practice.
Focus on subjective identification of cancer growth patterns and issues with tangential sectioning.

Main Results:

Despite guideline updates, high intra- and interobserver variability persists in prostate cancer grading.
Subjectivity in identifying cancer growth patterns remains a significant challenge.
Difficulties in reporting small cancer areas, tertiary Gleason patterns, and intraductal carcinoma persist.

Conclusions:

Prostate cancer grading guidelines have evolved, but practical implementation challenges remain.
Subjectivity and technical issues contribute to variability in grading, impacting prognostic accuracy.
Further refinement and training are needed to address problematic areas in prostate pathology reporting.