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AEP-mediated backbone cyclization of cyclotides-A chemoenzymatic method for cyclotide production

Yan Zhou1, Simon J de Veer1, Thomas Durek1

  • 1Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD, Australia.

Methods in Enzymology
|November 20, 2025
PubMed
Abstract

Keywords:
Asparaginyl endopeptidasesChemoenzymatic synthesisCyclizationCyclotideTranspeptidation

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