Systemic Inflammatory Response Index Is Associated With Insufficient Weight Loss After Bariatric Surgery

Area of Science:

• Bariatric Surgery
• Obesity Medicine
• Inflammation Biomarkers

Background:

• Obesity is a chronic condition associated with low-grade systemic inflammation.
• The systemic inflammatory response index (SIRI) is a key biomarker for assessing systemic inflammation.
• Evaluating SIRI's changes post-bariatric surgery is crucial for understanding its impact on inflammation and weight management.

Purpose of the Study:

• To analyze the evolution of SIRI before and one year after bariatric surgery.
• To determine the association between SIRI levels and insufficient weight loss (IWL) after surgery.
• To identify factors, including SIRI, associated with suboptimal weight loss outcomes.

Main Methods:

• An observational study included 348 patients undergoing bariatric surgery between 2013 and 2023.
• Preoperative and 1-year postoperative data on demographics, comorbidities, anthropometrics, and SIRI were collected.
• Statistical analyses assessed changes in SIRI and its correlation with weight loss and IWL.

Main Results:

• SIRI decreased significantly one year post-surgery, correlating with weight loss and BMI reduction.
• Higher postoperative SIRI values were significantly associated with insufficient weight loss (%EWL < 50% and Reinhold's classification).
• Multivariate analysis identified higher 1-year SIRI, older age, and female sex as independent predictors of IWL.

Conclusions:

• Bariatric surgery improves the inflammatory status in obese patients, as indicated by decreased SIRI.
• Elevated postoperative SIRI is a significant predictor of insufficient weight loss, suggesting a role for persistent inflammation in poor surgical outcomes.
• SIRI serves as a valuable biomarker for predicting bariatric surgery success and identifying patients at risk for IWL.