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Updated: Jan 10, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
Published on: July 29, 2022
α-synuclein in Parkinson's disease: a central point of convergence with depression
Ayesha M Yusuf1,2, Burcu Yener Ilce1, Hamid A Alhaj1,2
1Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Abstract:
Parkinson's Disease (PD) is a progressive neurodegenerative disorder. Depression, a prevalent comorbidity across all stages, exacerbates PD severity. α-synuclein aggregation, the hallmark of PD, drives pathways overlapping with depression. This review places α-synuclein at the nexus of mechanistic synergy between PD and depression, and incorporates secondary analyses of genomic and transcriptomic datasets to identify convergent genes and pathways, underscoring depression's potential as a biomarker for diagnosis and progression of PD.
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