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Updated: Jan 10, 2026

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
Published on: May 26, 2016
Computational modelling of hollow fibre haemodialysers: current status and future directions
Ruhit Sinha1, Anne E Staples2,3,4
1Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA, USA. ruhitsinha@vt.edu.
Abstract:
Current in silico dialyser models remain accurate only under narrowly constrained conditions. Advances in computing power and increasing levels of interdisciplinary collaboration, however, now set the stage for more robust computational haemodialyser models. In this review, we survey existing modelling approaches-long used to guide haemodialyser design and clinical nephrology practice-identify key unresolved challenges, and propose computational strategies poised to accelerate the development of dialyser technologies that better meet the needs of kidney failure patients.
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