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Evolution of Trunk and Extremities Infantile Hemangiomas: A Real-World Clinical Setting Study
Jose Maria Villa-Gonzalez1,2, Johanna Ramirez-Romero2,3, Borja Santos-Zorrozúa4
1Department of Dermatology, Cruces University Hospital, Barakaldo, Spain.
Pediatric Dermatology
|November 20, 2025
Summary
Infantile hemangiomas (IHs) on extremities respond well to propranolol. However, IHs on the chest and upper back show a poorer response, requiring closer monitoring and early intervention for better outcomes.
Area of Science:
- Dermatology
- Pediatrics
- Vascular Anomalies
Background:
- Infantile hemangiomas (IHs) can cause functional and aesthetic issues, particularly when located on the breast.
- Optimizing IH management requires understanding factors influencing treatment outcomes.
Purpose of the Study:
- To investigate factors influencing treatment response and outcomes of infantile hemangiomas based on location.
- To identify specific IH locations associated with treatment challenges.
Main Methods:
- Prospective study of 449 patients with IHs on the trunk and extremities.
- Data collected from Cruces University Hospital Vascular Anomaly Registry (January 2011 - December 2023).
- Analysis of treatment response, including propranolol efficacy and need for retreatment, correlated with lesion location.
Main Results:
- IHs located on the extremities demonstrated a significantly better response to propranolol treatment.
- Lesions in the anterior thoracic region (breast area) and upper back showed a poorer response to therapy.
- These specific locations were associated with a higher likelihood of requiring retreatment.
Conclusions:
- Location is a critical factor influencing the response to IH treatment.
- Early treatment and close follow-up are essential for IHs in challenging locations like the breast and upper back.
- Further research into tailored management strategies for IHs in specific anatomical sites is warranted.
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