Continuous Dual Glucose-Ketone Sensing Technology

Diabetic ketoacidosis (DKA) is a serious, life-threatening complication of diabetes. Although individuals who are at risk for DKA are advised to monitor ketone levels, adherence to monitoring is suboptimal. Continuous ketone monitoring is an emerging technology with the potential to address many of the limitations of current monitoring methods. Abbott Diabetes Care (Alameda, CA) has developed a continuous dual glucose-ketone sensor that measures both interstitial glucose and ketone levels simultaneously, transmitting the information in a continuous stream of data to users. However, one of the challenges in this effort was developing a sensor that can be factory-calibrated to ensure accuracy, safety, and user convenience. This article describes processes realizing factory calibration for the ketone sensor component.