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Published on: December 15, 2014
Diagnostic Value of miR-454-3p Combined With Color Doppler Ultrasound in Breast Cancer
Qian Huang1, Tao Han2, Jin Tian2
1Department of Ultrasound, Junlian County People's Hospital, Yibin, China.
Purpose:
To explore the diagnostic value of miR-454-3p combined with Color Doppler ultrasonography (CDUS) in BC, hoping to provide new insights for breast cancer (BC) diagnosis.
Methods:
A total of 205 female BC patients, 80 patients with benign breast diseases, and 50 healthy females were recruited. Serum miR-454-3p levels were measured by RT-qPCR, and all subjects underwent ultrasonic examination.
Results:
BC patients had significantly higher rates of irregular morphology, unclear boundaries, spiculations, shadowing, microcalcifications, aspect ratio ≥ 1, and blood flow grades II-III. Blood flow characteristics (RI, PI, and V max) were also notably elevated in BC compared to benign cases. miR-454-3p is significantly upregulated in both benign and BC groups. In BC patients, the expression levels of miR-454-3p were significantly elevated in those with larger tumors, higher histological grades, higher TNM stages, tumor lymph node metastasis, positive ER, and positive HER-2. The expression of miR-454-3p in BC patients was significantly correlated with ultrasound boundary, spiculated margins, echogenicity, aspect ratio, blood flow grading, and blood flow characteristics (RI, PI, and V max). miR-454-3p can improve the accuracy of CDUS in diagnosing BC.
Conclusion:
miR-454-3p has diagnostic value in BC, and its expression is significantly correlated with tumor deterioration. Combining miR-454-3p and CDUS can improve diagnostic accuracy, providing a reference for early clinical diagnosis of BC.
