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Airway changes in Asthma patients assessed by High-Resolution Computed Tomography: A cross-sectional study
H Lakshmi1, S N Megha2, M V Sharma3
1Consultant Pulmonologist, Alappuzha, Kerala, India.
La Clinica Terapeutica
|November 21, 2025
Summary
High-resolution computed tomography (HRCT) reveals significant airway wall thickening in poorly controlled asthma patients. This non-invasive imaging can help assess structural changes and guide asthma management strategies.
Area of Science:
- Pulmonology
- Radiology
- Medical Imaging
Background:
- Uncontrolled asthma can lead to irreversible airway remodeling.
- Assessing airway changes is crucial for effective asthma management.
- High-resolution computed tomography (HRCT) offers a non-invasive method to visualize airway structures.
Purpose of the Study:
- To evaluate HRCT findings in asthma patients.
- To compare HRCT parameters across different asthma control levels.
- To determine the relationship between asthma control and airway structural changes.
Main Methods:
- Observational, cross-sectional study of 50 asthma patients.
- HRCT thorax imaging was performed on all participants.
- Airway dimensions and structural changes were analyzed based on asthma control (well, partly, poorly controlled).
Main Results:
- Air trapping was the most frequent HRCT finding (68%).
- Patients with poorly controlled asthma exhibited significantly increased bronchial wall thickness and airway wall area (p<0.0001).
- Conversely, bronchial luminal area was significantly reduced in poorly controlled asthma (p<0.0001).
Conclusions:
- HRCT can detect significant airway wall thickening in poorly controlled asthma.
- HRCT parameters correlate with asthma control status.
- Further research is needed to explore HRCT's prognostic value and role in personalized asthma treatment.
Keywords:
Airway structural changesAsthmaHigh-Resolution Computed TomographyPartly controlled asthmaPoorly controlled asthmaMore Related Videos
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