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Updated: Jan 10, 2026

A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
Published on: January 17, 2014
Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe,
Francesca Saluzzo1,2, Chiara Sepulcri2,3, Alma Zinola2
1CRIMEDIM - Center for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università del Piemonte Orientale Novara, Italy.
Abstract:
The emergence and spread of an extensively drug-resistant (XDR) Mycobacterium tuberculosis lineage 4.8 cluster in Europe raises public health concerns. First reported in 2020 across Romania, Italy and the United Kingdom, this cluster progressed from multidrug-resistant (MDR) and pre-extensively drug-resistant (pre-XDR) to XDR, including resistance to pretomanid. Evidence of ongoing local transmission is available for Italy, where 10 cases were reported from 2021 to 2025. Strengthened whole genome sequencing-based surveillance is needed to inform timely, coordinated public health responses.
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