Related Experiment Video

Updated: Jan 10, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

695

The impact of glycated hemoglobin trajectories on hypertension risk: a retrospective cohort study

Yongbing Sun1, Yu Shen1, Ao Liu1

  • 1Department of Medical Imaging, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

Frontiers in Nutrition
|November 21, 2025
PubMed

Insights

Elevated glycated hemoglobin (HbA1c) levels and trajectories significantly increase hypertension risk. HbA1c above 5.70% and stable medium-to-high HbA1c patterns are key indicators for hypertension risk assessment.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Glycated hemoglobin (HbA1c) is a key indicator of long-term glucose control.
  • HbA1c levels have been associated with the development of hypertension.
  • Understanding this relationship is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the association between baseline HbA1c levels and hypertension risk.
  • To analyze the impact of HbA1c trajectories on hypertension development.
  • To identify HbA1c as a potential biomarker for hypertension risk.

Main Methods:

  • Retrospective cohort study of 10,138 adults from health screenings.
  • Analysis of hypertension incidence across baseline HbA1c tertiles and trajectories.
  • Latent class trajectory modeling (LCTM) and Cox proportional hazards models were used.

Main Results:

  • 34.05% of participants developed hypertension during follow-up.
  • Highest baseline HbA1c tertile showed significantly increased hypertension risk (HR=1.49).
  • Medium and high stable HbA1c trajectories were linked to increased risks (HR=1.38 and HR=2.71, respectively).
  • A J-shaped relationship was observed, with an inflection point at HbA1c=5.70%.

Conclusions:

  • Elevated baseline HbA1c (>5.70%) and medium-to-high stable HbA1c trajectories significantly elevate hypertension risk.
  • HbA1c is a valuable biomarker for assessing hypertension risk in adults.
  • These findings support proactive monitoring of HbA1c for cardiovascular health.
Abstract

Keywords:
glycated hemoglobinhealth screeninghypertensionprospective longitudinal studytrajectory analysis

More Related Videos

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.5K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

818

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
451
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Errors occurring during blood pressure monitoring01:25

Errors occurring during blood pressure monitoring

Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
1.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
720
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
763