Related Experiment Video
Updated: Jan 10, 2026

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
Published on: May 17, 2024
Pharmacokinetics and pharmacological activities of protopanaxatriol
Yeye Hu1, Jae Youl Cho1, Mi-Yeon Kim2
1Department of Integrative Biotechnology and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Abstract:
Protopanaxatriol (PPT) is an active metabolite derived from protopanaxatriol-type ginsenosides from Panax ginseng, displaying broad range of pharmacological activities against various diseases with higher efficacy. Since ginsenosides are known to be active components from ginseng, exploring biological activities and functions of the components could be important in terms of understanding ginseng's pharmacological roles. In this review, we aimed to report biological role of PPT by analyzing published literatures and databases. For this purpose, pharmacokinetics and pharmacological activities of PPT, including cardiovascular protection; neuroprotection; skin protection; immunomodulation; and anti-cancer, anti-inflammatory, and anti-diabetes effects were focused. In addition, we also discuss the underlying pharmacological mechanisms of action. This review highlights the importance of PPT for its overall efficacy and aims to inspire further exploration of its diverse potential applications.
More Related Videos
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
08:11Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
Related Concept Videos
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Pharmacodynamics: Overview and Principles
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...