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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Mechanisms of aging in the cardiovascular system: challenges and opportunities

Xiaoying Zhao1, Xinyue Yang1, Yumeng Lin2

  • 1Department of Gerontology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.

Frontiers in Immunology
|November 21, 2025
PubMed

Insights

Aging significantly impacts cardiovascular diseases (CVDs) in the elderly. This review explores how aging mechanisms affect the heart

Area of Science:

  • Gerontology
  • Cardiology
  • Molecular Biology

Background:

  • Cardiovascular diseases (CVDs) are a major health concern for the aging population.
  • The global population is aging, increasing the importance of managing CVDs.
  • Current medical management of CVDs in the elderly has limitations.

Purpose of the Study:

  • To review the mechanisms of aging and their specific impact on the cardiovascular system.
  • To explore the role of aging within the cardiac microenvironment.
  • To highlight age-related changes in the heart's cellular and molecular structure.

Main Methods:

  • Literature review of aging mechanisms.
  • Analysis of studies on cardiovascular aging.
  • Exploration of cardiac microenvironment changes due to aging.

Main Results:

  • Aging involves complex mechanisms that contribute to CVD development and progression.
  • Specific changes occur in the heart's cellular and molecular landscape with age.
  • The cardiac microenvironment is significantly altered by the aging process.

Conclusions:

  • Understanding aging mechanisms is crucial for addressing CVDs in the elderly.
  • Targeting age-related cardiac changes may offer new therapeutic strategies.
  • Further research into the cardiac microenvironment's role in aging is warranted.

Keywords:
agingcardiac agingcardiac microenvironmentinflammationtherapy

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