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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jan 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Research progress on molecular therapy for glaucoma (Review).

Weiwei Wang¹, Gangwei Cheng², Qi Zhou²

¹Glaucoma Center, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital, Northwest University, Xi'an, Shaanxi 710004, P.R. China.

Molecular Medicine Reports

|November 21, 2025

Summary

Glaucoma treatments are limited by managing intraocular pressure (IOP). Future therapies may target specific glaucoma mechanisms, including gene editing and molecular pathway modulation, for effective vision preservation.

Keywords:

gene therapy glaucoma mechanisms targeted therapy treatment

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Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Glaucoma is a leading cause of irreversible vision loss.
Current treatments primarily manage intraocular pressure (IOP) to slow disease progression.
Effective long-term glaucoma management remains a significant challenge.

Purpose of the Study:

To review the complex mechanisms underlying glaucoma.
To explore emerging therapeutic strategies targeting specific molecular pathways.
To guide future research for novel glaucoma interventions.

Main Methods:

Literature review of glaucoma pathogenesis.
Analysis of current and investigational treatment modalities.
Focus on molecular and genetic therapeutic approaches.

Main Results:

Glaucoma involves multifaceted mechanisms beyond elevated IOP.
Gene editing offers potential for glaucoma patients with known mutations.
Modulating gene expression and targeting metabolic pathways are promising avenues.

Conclusions:

Future glaucoma treatments will likely involve targeted molecular interventions.
Gene therapy and pathway modulation represent promising strategies.
Research is advancing towards effective, vision-preserving glaucoma solutions.