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Pediatric Spitzoid Melanoma: A Case Report
Jelena Roganović1, Mia Radošević2, Andrea Dekanić3
1Department of Pediatric Hematology and Oncology, Children's Hospital Zagreb, Zagreb, Croatia; Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia. jelena.roganovic@kdb.hr; jelena.roganovic02@gmail.com.
Acta Medica Academica
|November 21, 2025
Summary
Pediatric Spitzoid melanoma presents diagnostic and therapeutic challenges. Genetic testing revealed a CHEK2 mutation, highlighting the importance of genetic insights for family counseling and treatment decisions in childhood cancer.
Area of Science:
- Pediatric Oncology
- Dermatology
- Cancer Genetics
Background:
- Spitzoid melanoma in children is rare and poses diagnostic challenges.
- Genetic predisposition may play a role in its development.
- Understanding these factors is crucial for effective management.
Purpose of the Study:
- To discuss the diagnostic and therapeutic complexities of pediatric Spitzoid melanoma.
- To emphasize the role of genetic factors in childhood melanoma.
- To report a case with a specific genetic finding.
Main Methods:
- A case of a 7-year-old female with Spitzoid melanoma was analyzed.
- Histopathological examination and staging were performed.
- Germline genetic testing identified a pathogenic CHEK2 variant.
Main Results:
- The patient was diagnosed with pT2a Spitzoid melanoma.
- Wide local re-excision and sentinel lymph node biopsy were negative for malignancy.
- A pathogenic CHEK2 variant was identified, indicating a potential genetic predisposition.
Conclusions:
- This case highlights the importance of genetic insights in diagnosing and treating pediatric Spitzoid melanoma.
- The CHEK2 mutation identified underscores the need for genetic profiling and counseling.
- Further research into genetic factors in pediatric melanoma is warranted.
