Carbon dots derived from ginger for inhibiting inflammatory osteolysis
Xiao-Feng Shi1, Xin-Lin Jia1, Zhao-Fan Wu2
1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, P. R. China. MAOYQ1975@sh9hospital.org.cn.
Nanoscale
|November 21, 2025
Summary
Ginger-derived carbon dots (G-CDs) effectively treat inflammatory osteolysis by suppressing osteoclast activation and inflammation. This sustainable nanotherapeutic shows promise for bone diseases.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Immunology
Background:
- Inflammatory osteolysis, caused by overactive osteoclasts, presents a significant clinical challenge.
- Current therapies struggle to simultaneously reduce bone resorption and inflammation.
Purpose of the Study:
- To develop ginger-derived carbon dots (G-CDs) as a sustainable nanotherapeutic agent for inflammatory osteolysis.
- To investigate the anti-inflammatory and anti-osteolytic mechanisms of G-CDs.
Main Methods:
- G-CDs were synthesized using a hydrothermal method.
- In vitro studies assessed G-CDs' effects on osteoclastogenesis and inflammatory cytokine production.
- In vivo studies utilized an LPS-induced mouse calvarial osteolysis model.
Main Results:
- G-CDs demonstrated biocompatibility, reactive oxygen species scavenging, and anti-inflammatory effects.
- G-CDs inhibited RANKL-induced osteoclastogenesis by suppressing the NF-κB pathway.
- G-CDs reduced osteoclast markers, disrupted actin ring formation, and impaired bone resorption.
- In vivo, G-CDs significantly alleviated bone destruction and osteoclast activation.
Conclusions:
- G-CDs are a multifunctional, eco-friendly nanomaterial with potential for treating inflammatory osteolytic diseases.
- G-CDs offer a novel therapeutic strategy by targeting both inflammation and bone resorption.
