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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Related Experiment Video

Updated: Jan 10, 2026

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Recent Patents and Formulation Strategies for Osmotic Controlled Drug Delivery Systems: A Comprehensive Analysis.

Kirpa Shanker Tiwari1, Parijat Pandey2, Harish Dureja1

  • 1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.

Recent Advances in Drug Delivery and Formulation
|November 21, 2025
PubMed
Summary

Osmotic-controlled drug delivery systems offer sustained drug release, overcoming conventional limitations. This technology utilizes specific components and fabrication methods for improved therapeutic outcomes and patient compliance.

Keywords:
Controlled porosityorificeosmoticsemipermeable membrane.

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Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering
  • Drug Delivery Technology

Background:

  • Conventional drug delivery systems exhibit uncontrolled, immediate drug release, failing to maintain therapeutic concentrations.
  • This necessitates advanced delivery technologies for sustained and effective drug administration.

Purpose of the Study:

  • To review osmotic-controlled drug delivery systems, their components, fabrication methods, and patent landscape.
  • To highlight their potential in revolutionizing sustained-release formulations and improving patient outcomes.

Main Methods:

  • Comprehensive literature review of PubMed, Medline, Google Scholar, and patent databases (USPTO, WIPO).
  • Inclusion of peer-reviewed articles, patents, and relevant studies.
  • Standardized data extraction for consistency and reliability.

Main Results:

  • Osmotic systems provide sustained drug release, overcoming conventional limitations.
  • Key components include drugs, osmotic agents, semipermeable membranes, and pore-forming agents.
  • Formulation parameters like drug solubility, orifice size, and osmotic pressure control release rates.

Conclusions:

  • Fabrication methods (drilling, indentation, leaching) create delivery apertures for osmotic pumps.
  • Review of historical and recent patents reveals significant innovation in osmotic delivery.
  • Osmotic systems enhance therapeutic outcomes and patient compliance through controlled drug release.