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Recent Patents and Formulation Strategies for Osmotic Controlled Drug Delivery Systems: A Comprehensive Analysis
Kirpa Shanker Tiwari1, Parijat Pandey2, Harish Dureja1
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.
Introduction:
Conventional drug delivery systems often release drugs immediately at an uncontrolled rate, failing to maintain a sustained and effective concentration at the site of action. This limitation necessitates the exploration of more advanced delivery technologies.
Methods:
A comprehensive literature review was conducted using databases such as PubMed, Medline, Google Scholar, and patent repositories, including the United States Patent and Trademark Office (USPTO) and the World Intellectual Property Organization (WIPO). The inclusion criteria covered peer-reviewed articles, patents, and relevant studies. Data were extracted using a standardized form to ensure consistency and reliability across sources.
Results:
Osmotic-controlled drug delivery systems have demonstrated the ability to overcome limitations of conventional methods by providing sustained drug release over extended periods. Core components of these systems include drugs, osmotic agents, semipermeable membranes, plasticizers, wicking agents, and pore-forming agents. Key formulation parameters such as drug solubility, orifice size, and osmotic pressure play a pivotal role in controlling drug release rates.
Discussion:
Various fabrication methods, such as mechanical or laser drilling, indentation, and the inclusion of leaching substances, can be employed to create delivery apertures in osmotic pumps. This review offers insights into both historical and recent patents related to osmotic-controlled delivery systems, highlighting their potential to revolutionize sustained-release formulations.
Conclusion:
This review highlights the potential of osmotic-controlled drug delivery systems to improve therapeutic outcomes and patient compliance by enabling sustained and controlled drug release. Key formulation components and recent technological innovations, including patents, are highlighted for their role in enhancing system performance and guiding future pharmaceutical development.
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