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Increasing Physical Activity via Provider Support and Engagement Using a Digital Health Platform in Adults With

Dawn M Ehde1, Sarah B Simmons1, Kevin N Alschuler1

  • 1Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States.

JMIR Research Protocols
|November 21, 2025
PubMed
Summary

This study tests the ExerciseRx digital health platform to see if it improves physical activity and reduces symptoms in adults with multiple sclerosis (MS). Results will show if this app effectively promotes exercise and enhances well-being for MS patients.

Keywords:
clinical trialdigital healthexercisemobile appmultiple sclerosisphysical activitystep count

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Area of Science:

  • Digital health interventions
  • Multiple Sclerosis (MS) management
  • Physical activity promotion

Background:

  • Physical activity benefits are known for MS, but most patients are inactive.
  • Existing activity trackers lack EHR integration, hindering clinical monitoring.
  • ExerciseRx bridges this gap, connecting smartphone activity data to EHRs.

Purpose of the Study:

  • To evaluate the ExerciseRx digital health platform's efficacy in improving physical activity, symptoms, and functioning in adults with MS.
  • To compare the ExerciseRx platform against a waitlist, usual care control group.

Main Methods:

  • A 12-week randomized controlled trial involving 106 ambulatory adults with MS.
  • Intervention group uses the ExerciseRx app; control group receives usual care.
  • Primary outcome: change in average daily step count. Secondary outcomes: symptoms, functional outcomes, and qualitative feedback.

Main Results:

  • Study funded Oct 2023, enrollment began March 2024, ongoing through Dec 2025.
  • As of July 2025, 85 participants enrolled.
  • Data analysis and dissemination planned for Jan 2026.

Conclusions:

  • The trial will yield crucial data on the effectiveness of a novel digital health tool for physical activity promotion in MS.
  • Findings will inform the integration of digital health solutions in MS care.
  • This research addresses a significant need for accessible and monitorable physical activity interventions for individuals with MS.