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Copaiba Oil-Resin Reduces the Alveolar Bone Damage Triggered by Apical Periodontitis in Rats.

Rayssa Maitê Farias Nazário¹, Deborah Ribeiro Frazão¹, Leonardo Oliveira Bittencourt¹

¹Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.

International Endodontic Journal

|November 21, 2025

Summary

Copaiba oil-resin significantly reduced bone loss and preserved collagen fibers in rats with apical periodontitis. This natural compound shows promise for treating bone loss associated with this dental condition.

Keywords:

Copaifera reticulata Ducke apical periodontitis complementary therapies endodontics phytotherapy

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Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Area of Science:

Biomedical Science
Dental Research
Pharmacology

Background:

Apical periodontitis is a common inflammatory condition leading to bone destruction.
Current treatments may have limitations, necessitating exploration of novel therapeutic agents.
Natural compounds are increasingly investigated for their potential therapeutic benefits.

Purpose of the Study:

To evaluate the efficacy of copaiba oil-resin in managing induced apical periodontitis in a rat model.
To assess the impact of copaiba oil-resin on bone lesion volume, collagen integrity, and tissue preservation.

Main Methods:

Apical periodontitis was induced in Wistar rats by exposing pulp chambers.
Copaiba oil-resin was administered systemically to the treatment group.
Histopathological analysis, picrosirius red staining, and microcomputed tomography were employed.

Main Results:

Copaiba oil-resin significantly reduced the volume of bone lesions.
The treatment preserved collagen fibers and reduced their degradation.
Histological examination revealed reduced tissue damage and preserved alveolar bone.

Conclusions:

Copaiba oil-resin demonstrates potential as an adjunct therapy for apical periodontitis.
It effectively mitigates bone loss and aids in maintaining bone quality.
Further research into copaiba oil-resin for endodontic applications is warranted.