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Related Experiment Video

Updated: Jan 10, 2026

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
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An Encouraging Approach to Complex ASDs: A Multicenter Study.

Rasit Aktas1, Nazmi Narin2, Kaan Yildiz3

  • 1Department of Pediatric Cardiology, Health Sciences University Izmir Tepecik Education And Research Hospital, Izmir, TR 35020, Turkey. rasitaktas1989@outlook.com.

Pediatric Cardiology
|November 21, 2025
PubMed
Summary
This summary is machine-generated.

Transcatheter closure of complex atrial septal defects (ASDs) is effective and safe, even in challenging cases like large defects or rim deficiencies. This minimally invasive approach achieved a high success rate with few complications in experienced centers.

Keywords:
Complex atrial septal defectsPediatricTranscatheter closure

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Pediatric Cardiology

Background:

  • Percutaneous closure is common for atrial septal defects (ASDs).
  • Surgery may be preferred for complex ASDs (large defects, rim issues, aneurysms, multifenestration, young age/weight).
  • Complex ASDs present unique challenges for transcatheter closure.

Purpose of the Study:

  • To evaluate the safety and efficacy of transcatheter closure for complex ASDs.
  • To assess success and complication rates in a cohort with challenging anatomical features.

Main Methods:

  • Retrospective analysis of 51 patients with complex ASDs undergoing transcatheter closure (Jan 2021 - Aug 2024).
  • Data collected included patient demographics, defect characteristics (size, rim, septum), and procedural outcomes.
  • Complexities included multifenestrated/multiple defects, aneurysmal septum, young age, large defects, and various rim deficiencies.

Main Results:

  • The study included 51 patients with diverse complex ASD features.
  • Two device embolizations occurred; otherwise, no complications were reported.
  • The overall success rate for transcatheter closure was 96.08%.

Conclusions:

  • Transcatheter closure is a safe and effective option for complex ASDs.
  • Low complication rates and high success are achievable in experienced centers.
  • Minimally invasive closure is feasible even with challenging anatomical variations.