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Updated: Jan 10, 2026
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circular RNAs and endothelial dysfunction: mechanistic crosstalk and emerging therapeutic perspectives
Zaheer Ud Din1,2,3,4, Jing Xia1,3, Zhu-Guo Wu1,2
1Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China.
Cellular and Molecular Life Sciences : CMLS
|November 21, 2025
Summary
Circular RNAs (circRNAs) are emerging as key players in endothelial dysfunction, a hallmark of many diseases. Understanding circRNAs offers new therapeutic avenues for conditions like atherosclerosis and diabetes.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Genetics
Background:
- Endothelial cell (EC) dysfunction is central to numerous human diseases, including atherosclerosis, hypertension, and diabetes.
- Alterations in vascular endothelium are linked to a wide spectrum of conditions, impacting capillary regulation.
- Impaired endothelial function is a recognized characteristic feature of many complex human diseases.
Purpose of the Study:
- To elucidate the mechanisms of circular RNAs (circRNAs) in endothelial dysfunction.
- To explore the role of circRNAs in diseases associated with endothelial dysfunction.
- To highlight the potential of circRNAs as therapeutic targets for endothelial dysfunction-related diseases.
Main Methods:
- This review synthesizes current research on circRNAs and endothelial dysfunction.
- Literature analysis focusing on molecular mechanisms and disease associations.
- Exploration of existing studies on non-coding RNAs in endothelial dysfunction.
Main Results:
- Circular RNAs (circRNAs) are increasingly recognized for their critical roles in cellular processes.
- The specific involvement of circRNAs in endothelial dysfunction-related diseases is not yet fully understood.
- Existing research on non-coding RNAs provides a foundation for investigating circRNAs.
Conclusions:
- Investigating circRNAs in endothelial dysfunction holds significant promise for novel insights.
- Understanding circRNAs could lead to innovative therapeutic strategies for atherosclerosis, hypertension, diabetes, and CAD.
- Further research into circRNAs is crucial for advancing the treatment of endothelial dysfunction-related diseases.
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