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Updated: Jan 10, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Exploring the biological mechanisms of obesity affecting breast cancer from a multidimensional perspective
Yingying Rao1, Suyuan Wang2, Xianglin Liu1
1Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Abstract:
Obesity, a global health challenge, significantly contributes to breast cancer pathogenesis through chronic inflammation and metabolic dysregulation. This review summarizes the biological mechanisms through which obesity influences the development and progression of breast cancer, focusing on endocrine regulation, intercellular communication, gut microbiota interactions, obesity-associated genetic polymorphisms, and circadian rhythm homeostasis. The aim is to provide a theoretical foundation for the diagnosis and treatment of obesity-related breast cancer.
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