Related Experiment Video
Updated: Jan 6, 2026
04:03
Application of Laparoscopic Ultrasonography in Primary Choledochal Suture during Combined Two-lens Surgery
Published on: March 28, 2025
427
Optimizing Care in Primary Biliary Cholangitis: Current Treatments and the Second-Line Decision
Gina Choi1,2, Arun B Jesudian3, Sammy Saab4,5
1Departments of Medicine and Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Digestive Diseases and Sciences
|November 21, 2025
Summary
Primary biliary cholangitis (PBC) treatment is evolving. New therapies offer hope for patients with inadequate response to ursodeoxycholic acid (UDCA), improving quality of life beyond liver function tests.
Area of Science:
- Hepatology
- Autoimmune Diseases
- Gastroenterology
Background:
- Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease.
- Early diagnosis and treatment are crucial to prevent advanced liver disease.
- Ursodeoxycholic acid (UDCA) is the first-line treatment but has limitations.
Purpose of the Study:
- To review current treatment strategies for PBC.
- To discuss the role of new second-line therapies like elafibranor and seladelpar.
- To emphasize updating treatment guidelines to include patient-reported outcomes.
Main Methods:
- Literature review of PBC treatment.
- Analysis of recent FDA approvals for PBC therapies.
- Discussion of clinical implications for patient management.
Main Results:
- UDCA improves survival but is inadequate for some patients.
- Elafibranor and seladelpar show promise in improving liver enzymes and patient symptoms.
- These new therapies have potential adverse events.
Conclusions:
- Current PBC treatment guidelines need updating.
- Early evaluation of UDCA response and incorporation of patient-reported outcomes are essential.
- Personalized medicine approaches should prioritize symptom burden and quality of life alongside biochemical markers like ALP.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
282
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
282
01:30Acute Pancreatitis II: Clinical Manifestations and Management
693
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
693
01:29Inflammatory Bowel Disease IV: Pharmacological Management
427
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
427
01:17Chronic Bowel Disorders: Introduction
721
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
721
01:27Peripheral Artery Disease III: Interprofessional Care
215
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
215
01:23Gastritis III: Clinical Manifestations and Management
1.1K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.1K