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Published on: January 7, 2019
Limonoids and protolimonoid from Swietenia macrophylla
Yun-Peng Sun1, Wen-Fang Jin1, Ze-Rong Xu1
1School of Pharmacy, Anhui University of Chinese Medicine, Anhui Province Key Laboratory of Bioactive Natural Products, Hefei, P.R. China.
Abstract:
Two new limonoids, swieteliacates V and W (1 and 2), and a new protolimonoid, 21α-ethoxyprotoxylocarpin E (3), together with six known limonoids (4-9), were isolated from the leaves of Swietenia macrophylla. Their structures, including absolute configurations, were determined through spectroscopic analysis (HR-ESI-MS, 1D and 2D NMR), and ECD calculations. Compounds 2, 6, and 9 were found to inhibit hepatic glucose production in MPH cells induced by forskolin (FSK) and dexamethasone (Dex), while compounds 5 and 6 promoted lipid accumulation induced by free fatty acids.
