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Updated: Jan 6, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
DNA-Compatible Synthesis of α-Aminophosphonate Scaffolds via Kabachnik-Fields Reaction
Ik Hwan Choi1, Jihoon Lee2, Hyewon Seo2
1KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea.
Abstract:
In this study, we report a DNA-compatible synthetic approach for the construction of α-aminophosphonate derivatives─phosphorus-containing bioisosteres of α-amino acids─via the Kabachnik-Fields reaction. This multicomponent transformation proceeds under mild conditions, demonstrates a broad substrate scope, and exhibits excellent compatibility with subsequent enzymatic ligation. Its successful application to a mock library synthesis further underscores the potential of this method as a valuable addition to the toolbox of DEL-compatible chemistry.
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